Description

We are seeking a highly motivated Postdoctoral Research Fellow to join an NIH-funded multidisciplinary research team focused on developing nanobody-based imaging and delivery strategies for precision molecular fingerprinting of SAbO clearance flow dynamics using a targeted near-infrared (NIR)-nanobody for early detection of AD. The project integrates molecular biology, imaging, and in vivo mouse studies to investigate SAbO biology and establish novel diagnostic approaches.

Requirements

• Perform mouse studies, including tissue collection following euthanasia, and downstream processing of ocular, brain and other tissues.
• Be proficient in mouse eye and brain dissections for assays below.
• Develop and plan projects for experimental work to identify cellular mechanisms and novel treatment strategies associated with the ocular diseases and Alzheimer’s disease, in consultation with supervisors.
• Conduct and optimize laboratory assays such as:
        Immunohistochemistry (IHC) and immunofluorescence (IF)
        Enzyme-Linked Immunosorbent Assay (ELISA)
        Western blotting (WB)
        Confocal microscopy and image acquisition/analysis
• Execute in vitro, ex vivo, and in vivo experiments aligned with project aims.
• Analyze and interpret experimental data, ensuring rigor and reproducibility.
• Maintain accurate and detailed laboratory records in compliance with NIH and institutional guidelines. 
• Contribute to experimental design, protocol development, and troubleshooting.
• Prepare manuscripts, figures, and presentations for publication and scientific meetings.
• Collaborate with multidisciplinary team members and participate in lab meetings.
• Ensure compliance with institutional animal care and use protocols (IACUC).