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Biohaven Pharmaceuticals
New Haven, Connecticut, United States
20 days ago
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Biohaven Pharmaceuticals
New Haven, Connecticut, United States
20 days ago

Description

Biohaven is a commercial-stage biopharmaceutical company with a portfolio of innovative, best-in-class therapies to improve the lives of patients with debilitating neurological and neuropsychiatric diseases, including rare disorders. Biohaven's neuroinnovation portfolio includes FDA-approved NURTEC ODT (rimegepant) for the acute and preventive treatment of migraine and a broad pipeline of late-stage product candidates across three distinct mechanistic platforms: CGRP receptor antagonism for the acute and preventive treatment of migraine; glutamate modulation for obsessive-compulsive disorder, Alzheimer's disease, and spinocerebellar ataxia; and MPO inhibition for neurodegenerative disease, including ALS. More information about Biohaven is available at www.biohavenpharma.com.

Our progress is fueled by an entrepreneurial organizational structure and an impressive range of experience in drug development along with the confident support of top-tier biopharma investors. The Biohaven culture emphasizes passion, teamwork and high-performance to create value for patients, investors, and employees. As a patient centric organization, they are seeking individuals that have a consistent record of performance, are passionate about better patient care, dynamic team players, and proactive problem-solvers. At Biohaven, it’s about high-performing teams doing meaningful work to positively impact patients. We are seeking outstanding candidates who wish to be part of a highly engaged, ground floor, rapid paced, high growth company. 

Research Scientist In Vivo/in Vitro

Principal Responsibilities:

  • Under minimal supervision design, plan, and independently perform in vivo efficacy studies in mice using various disease models in therapeutic areas including Immuno-Oncology, CNS, Autoimmunity and Inflammatory/Renal/Liver diseases
  • Under minimal supervision design and perform in vitro experiments to screen compounds
  • Design and set up novel in vitro model systems for compound screening
  • Maintain cultures of adherent and non-adherent cell lines
  • Perform ELISA and multiplex cytokine analyses
  • Perform antibody purification, Western Blot, and immunoprecipitation
  • Synthesize results across experiments and programs in PowerPoint presentations and present to peers
  • Execute PK/PD studies in mice
  • Perform dosing (IV, SC, IP, PO), measure tumors, harvest plasma, urine, organs/tissues for subsequent ex vivo
  • Perform bleeding, perfusion, oral gavage, and intraperitoneal lavage as required
  • Serve as a liaison between CRO for outsourced PK/PD projects
  • Maintain detailed records of studies performed, archive study protocols and data


Requirements

Qualifications:

  • S. or Ph.D. in Immunology, Cell Biology, Biochemistry or related discipline, 0-10+ years post-graduate training (position title will depend on experience)
  • 3+ years experience with developing and performing in vitro cell-based and biochemical assays using methods such as Western Blot, Immunoprecipitation, ELISA, and flow cytometry
  • Experience working with cell lines is essential
  • Experience handling animals, performing dosing, and other techniques, described below are essential
  • Skilled in performing studies to interrogate in vivo efficacy of novel therapies
  • Experience with antibody purification by affinity chromatography
  • Demonstrated ability to plan and execute experiments, analyze and interpret data, and report conclusions
  • Ability to independently manage daily workflow
  • Strong critical thinking and problem-solving abilities
  • Commitment to scientific excellence and furthering knowledge in the field
  • Proven interpersonal and written/oral communication skills
  • Collaborative, enthusiastic and proactive attitude a must
  • Works successfully in cross-functional teams by contributing data and ideas
  • Will have ownership of several projects. Must have high self-motivation and the ability to multi-task
  • Ability to work independently and as part of a team

Job Information

  • Job ID: 59196818
  • Location:
    New Haven, Connecticut, United States
  • Position Title: Research Scientist
  • Company Name: Biohaven Pharmaceuticals
  • Job Function: Research Scientist
  • Job Type: Full-Time
  • Min Education: Master's Degree
  • Min Experience: 2-3 Years

Please refer to the company's website or job descriptions to learn more about them.

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